PX-2, also recognized as 5F-APP-PINACA, FU-PX, and PPA(N)-2201, represents an indazole-based synthetic cannabinoid that has been available for online purchase under the designation of a designer drug. This compound incorporates a phenylalanine amino acid amide within its structural composition.

IUPAC name
CAS Number2365471-47-0 
Chemical and physical data
Molar mass396.466 g·mol−1


On November 10, 2014, Sweden’s public health agency proposed the classification of PX-2 as a hazardous substance. PX-2 has been included in the Fifth Schedule of the Misuse of Drugs Act (MDA) in Singapore, making it illegal in the country as of May 2015. Additionally, as of October 2015, PX-2 has been classified as a controlled substance in China.


  • What is PX-2?
  • PX-2 is a synthetic cannabinoid known by various names, such as 5F-APP-PINACA, FU-PX, and PPA(N)-2201. It is designed to mimic the effects of natural cannabinoids and has been available as a designer drug.
  • Why did Sweden’s public health agency propose classifying PX-2 as a hazardous substance?
  • On November 10, 2014, Sweden’s public health agency suggested classifying PX-2 as a hazardous substance due to concerns about its potential health risks and effects.
  • Is PX-2 illegal in Singapore?
  • Yes, PX-2 is considered illegal in Singapore as it is listed in the Fifth Schedule of the Misuse of Drugs Act (MDA). This designation makes its possession, sale, or use unlawful in the country starting May 2015.
  • Is PX-2 a controlled substance in China?
  • Yes, as of October 2015, PX-2 is categorized as a controlled substance in China, reflecting government regulations on its use and distribution.
  • What are the known effects of PX-2?
  • The effects of PX-2 can vary, but it is typically sought after for its potential to produce experiences similar to those induced by natural cannabinoids. These effects may include altered perception, relaxation, and changes in mood.
  • What are the potential health risks associated with PX-2?
  • Synthetic cannabinoids like PX-2 can carry various health risks, including adverse psychological and physical effects. Due to their unpredictable nature, these substances can lead to severe health consequences, addiction, and even overdose.
  • Is PX-2 legal in other countries?
  • The legal status of PX-2 may vary from one country to another. It’s essential to check the specific regulations and laws in your region regarding this substance.
  • Where can I find more information or seek help regarding PX-2?
  • If you have questions or concerns or require assistance related to PX-2, it is advisable to consult with relevant authorities, healthcare professionals, or addiction specialists who can provide guidance and information. Your local public health agency may also be a valuable resource.


  1. PX-2: Explore the synthetic cannabinoid PX-2, known by various names, and understand its properties and effects. Cayman Chemical provides valuable information about this substance.
  2. Identification and Characterization: Learn about the identification and analytical characterization of synthetic cannabinoids, including ADB-BICA, NNL-1, NNL-2, and PPA(N)-2201. This research delves into the composition and properties of these compounds.
  3. Metabolism Studies: Gain insights into the metabolism of synthetic cannabinoids PX-1 and PX-2 through comprehensive phase I metabolism studies. Understand how these compounds are processed within the body and the potential implications.
  4. Health Classification: Stay informed about the proposed classification of cannabinoids as substances dangerous to health. Explore the considerations and potential risks associated with these compounds.
  5. Legal Status in Singapore: Discover the legal status of PX-2 in Singapore, where it is subject to regulatory controls and restrictions.
  6. Regulations in China: Understand the regulations and controls on synthetic cannabinoids in China. Learn about the measures in place to manage their distribution and use.

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