25C-NBF (also known as 2C-C-NBF or NBF-2C-C) represents a chemical compound derived from the phenethylamine hallucinogen 2C-C. It exhibits significant potency as a partial agonist for the human 5-HT2A receptor.

CAS Number1539266-21-1 


On January 26, 2016, the Swedish Riksdag incorporated 25C-NBF into the Narcotic Drugs Punishments Act, categorizing it under Swedish Schedule I. This category encompasses “substances, plant materials, and fungi which normally do not have medical use.” The regulation was published by the Medical Products Agency (MPA) and specifically listed 25C-NBF as 2-(4-chloro-2,5-dimethoxyphenyl)-N-(2-fluorobenzyl)ethanamine.[4]
United Kingdom:
In the United Kingdom, this substance falls under the Class A category due to the N-benzyl phenethylamine catch-all clause within the Misuse of Drugs Act 1971.


  • What is 25C-NBF? 25C-NBF, also known as 2C-C-NBF or NBF-2C-C, is a derivative of the phenethylamine hallucinogen 2C-C. It acts as a highly potent partial agonist for the human 5-HT2A receptor.
  • Is 25C-NBF legal? The legal status of 25C-NBF varies by country. It’s essential to check the specific regulations in your region, as it may be classified as a controlled substance in some places.
  • What are the effects of 25C-NBF? 25C-NBF is known for its hallucinogenic effects, but these can vary from person to person. Users have reported altered perceptions, vivid visuals, and changes in thought patterns. It’s crucial to remember that these effects can be unpredictable and, in some cases, intense.
  • How is 25C-NBF consumed? Typically, 25C-NBF is ingested orally, often in the form of blotter paper or as a powder. However, the exact method of consumption can vary, and it’s essential to be cautious and informed about the specific product you are using.
  • What are the risks associated with 25C-NBF use? The use of 25C-NBF can have several potential risks, including hallucinations, anxiety, paranoia, and, in some cases, physical discomfort. There is also a risk of misidentification, as substances may be sold as something else.
  • Is 25C-NBF safe to use? The safety of 25C-NBF has not been thoroughly studied, and its long-term effects are largely unknown. Due to the potential risks and lack of scientific research, using this substance is not considered safe.
  • Is 25C-NBF the same as other 2C compounds? While 25C-NBF is related to other 2C compounds in its chemical structure, it has its own distinct effects and properties. It’s essential not to assume that the effects of 25C-NBF are the same as other substances in the 2C family.
  • Can 25C-NBF be addictive? There is limited information on the addictive potential of 25C-NBF. However, hallucinogens, in general, are not typically considered physically addictive. Psychological addiction can still be a concern for some individuals.
  • Is it possible to overdose on 25C-NBF? Yes, it is possible to overdose on 25C-NBF. An overdose may result in severe physical and psychological reactions, which can be life-threatening. It’s crucial to use this substance, if at all, with extreme caution and in very small amounts.
  • Where can I find more information about 25C-NBF? It’s essential to stay informed about the substances you are considering using. Consult reliable sources, and if you have further questions or concerns, consider seeking guidance from a healthcare professional.


  1. Anvisa (2023-07-24). “RDC Nº 804 – Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial” [Collegiate Board Resolution No. 804 – Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Published in Diário Oficial da União on 2023-07-25. Archived from the original on 2023-08-27. Retrieved on 2023-08-27.
  2. Hansen M, Phonekeo K, Paine JS, Leth-Petersen S, Begtrup M, Bräuner-Osborne H, Kristensen JL (March 2014). “Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists.” Published in ACS Chemical Neuroscience, 5(3), 243–249. doi:10.1021/cn400216u. PMC 3963123. PMID 24397362.
  3. Hansen M (2010-12-16). “Design and Synthesis of Selective Serotonin Receptor Agonists for Positron Emission Tomography Imaging of the Brain.” (Ph.D. thesis) from the University of Copenhagen. doi:10.13140/RG.2.2.33671.14245.
  4. “Archived copy” (PDF). Archived from the original on 2017-10-31.
  5. “The Misuse of Drugs Act 1971 (Ketamine etc.) (Amendment) Order 2014.” Available at www.legislation.gov.uk.
  6. “Explore N-(2C-C)-Fentanyl | PiHKAL · info” on isomerdesign.com.

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