25-C-NBOH (2C-C-NBOH or NBOH-2CC) is a chemically derived compound from the phenethylamine hallucinogen 2C-C. This substance has gained popularity as a designer drug. Notably, it exhibits comparable serotonin receptor affinities to the more widely recognized compound, 25C-NBOMe.

IUPAC name
CAS Number1391488-16-6 
PubChem CID125181419
Chemical and physical data
Molar mass321.80 g·mol−1

Analytical chemistry

25C-NBOH, much like other NBOH substances, degrades when subjected to standard Gas Chromatography (GC) conditions, forming 2C-C. An alternative approach for the dependable identification of 25I-NBOH through Gas Chromatography-Mass Spectrometry (GC/MS) could similarly be applied to the analysis of 25C-NBOH.


In the United Kingdom, this compound is categorized as a Class A drug due to its inclusion under the N-benzylphenethylamine catch-all clause in the Misuse of Drugs Act 1971.


  • What is 25C-NBOH?
  • 25C-NBOH is a derivative of the phenethylamine hallucinogen 2C-C. It belongs to a class of compounds known for their psychoactive effects.
  • How is 25C-NBOH used?
  • 25C-NBOH is primarily used recreationally, typically by ingesting it orally or sublingually. It is considered a designer drug with hallucinogenic properties.
  • What are the effects of 25C-NBOH?
  • The effects of 25C-NBOH can include altered perception, hallucinations, mood changes, and sensory distortions. These effects may vary depending on the dose and individual reactions.
  • Is 25C-NBOH legal?
  • The legal status of 25C-NBOH varies by country. In some places, it may be categorized as a controlled substance; in others, it could be subject to legal restrictions.
  • Is 25C-NBOH safe to use?
  • The safety of using 25C-NBOH is a subject of concern. Like other hallucinogenic substances, it can have unpredictable effects on individuals. Moreover, the purity and composition of the substance can vary significantly, increasing potential risks.
  • What are the risks associated with 25C-NBOH?
  • Risks associated with 25C-NBOH use include hallucinations, anxiety, paranoia, and, in extreme cases, adverse physical reactions. Overdosing can be life-threatening.
  • How can I minimize the risks of 25C-NBOH use?
  • It is crucial to be well-informed about the substance, its effects, and potential consequences to reduce risks. If one chooses to use it, doing so in a safe and controlled environment with a trusted person present is advisable.
  • Is 25C-NBOH addictive?
  • There is limited research on the addictive potential of 25C-NBOH. However, like other hallucinogens, it is generally not considered highly addictive in the traditional sense.
  • Can 25C-NBOH be detected in drug tests?
  • The detection of 25C-NBOH depends on the specific drug test being used. It may not be a standard substance tested for in many conventional drug screenings.
  • Where can I find more information about 25C-NBOH?
  • For more information about 25C-NBOH, it is advisable to consult reliable sources of scientific literature and, if necessary, seek guidance from healthcare professionals. Always prioritize your safety and well-being.


  1. Anvisa’s Resolution: Anvisa’s “Collegiate Board Resolution No. 804” outlines the Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control. This regulation was published in Brazilian Portuguese on July 24, 2023, in the Diário Oficial da União, with archived copies available as of August 27, 2023.
  2. Pharmacological Research: In March 2014, researchers led by Hansen M conducted a study focusing on the synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists. The results were published in the “ACS Chemical Neuroscience” journal, shedding light on the pharmacological aspects of these compounds.
  3. Selective Serotonin Receptor Agonists: Hansen M’s Ph.D. thesis, completed on December 16, 2010, at the University of Copenhagen, delved into the design and synthesis of selective serotonin receptor agonists. This work contributed to the development of compounds with potential applications in positron emission tomography imaging of the brain.
  4. Blotter Paper Seizures: In Brazil, researchers, including Arantes LC, Júnior EF, de Souza LF, Cardoso AC, Alcântara TL, Lião LM, and others, identified a 2A receptor agonist in blotter paper seizures in 2017. This discovery was published in “Forensic Toxicology” and played a role in understanding the presence of these substances in illicit drugs.
  5. NBOH Drug Identification: In 2019, Machado Y, Lordeiro RA, Neto JC, Alves RB, and Piccin E identified new NBOH drugs in seized blotter papers, specifically 25B-NBOH, 25C-NBOH, and 25E-NBOH. Their findings were published in “Forensic Toxicology,” providing insights into the composition of these illicit substances.
  6. Preventing Misidentification: A group of researchers, including Neto JC, Andrade AF, Lordeiro RA, Machado Y, Elie M, and Júnior EF, took steps to prevent the misidentification of 25I-NBOH as 2C-I in routine GC–MS analyses. Their work, published in “Forensic Toxicology,” aimed to enhance the accuracy of analytical methods used in substance identification.
  7. Legislation Amendment: The “Misuse of Drugs Act 1971 (Ketamine etc.) (Amendment) Order 2014” in the United Kingdom played a role in regulating certain substances, reflecting legal efforts to control the use and distribution of specific compounds.

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