25E-NBOMe (also known as 2C-E-NBOMe or NBOMe-2C-E) is a chemical derivative originating from the phenethylamine 2C-E. It exhibits analogous behaviour to its counterparts, including 25I-NBOMe, known for their powerful activation of the 5HT2A receptor. This substance has been circulated as a recreational drug, eliciting effects comparable to related compounds like 25I-NBOMe and 25C-NBOMe in human subjects.

IUPAC name
CAS Number1354632-14-6
PubChem CID118796522
CompTox Dashboard (EPA)DTXSID901014188
Chemical and physical data
Molar mass329.440 g·mol−1


NBOMe substances are frequently linked to severe toxicity and fatalities. Scientific investigations into the NBOMe family of compounds have revealed their neurotoxic and cardiotoxic properties. Commonly, users of NBOMe encounter issues such as sympathomimetic toxicity, including vasoconstriction, hypertension, tachycardia, and hallucinations. Symptoms associated with NBOMe poisoning encompass agitation, aggression, seizures, hyperthermia, diaphoresis, hypertonia, rhabdomyolysis, and even death. Instances of NBOMe intoxication often exhibit signs resembling serotonin syndrome, with the likelihood of seizures being notably higher than other psychedelic substances.
The sale of NBOMe and NBOHs as LSD on blotter papers is not uncommon despite their bitter taste and distinct safety profiles. Unlike LSD, known for its low incidence of acute toxicity at recreational doses, fatalities associated with NBOMe intoxication suggest a significant number of users ingested the substance under the false belief that it was LSD. The lack of comprehensive documentation regarding NBOMe consumption leaves the long-term effects of the importance largely unknown. Typically, NBOMe compounds are administered sublingually, resulting in tongue and mouth numbness, followed by a metallic chemical taste, a critical differentiator from LSD.
Regarding its neurotoxic and cardiotoxic actions, many NBOMe compounds exhibit potent agonist activity at additional 5-HT receptors, with prolonged activation of 5-HT2B potentially leading to cardiac valvulopathy, especially with high doses and chronic use. The compounds’ high affinity for adrenergic α1 receptors contributes to their stimulant-like cardiovascular effects. In laboratory studies, 25C-NBOMe has shown cytotoxic effects on various neuronal cell lines and cardiomyocytes, with implications for MAPK/ERK cascade activation and inhibition of Akt/PKB signalling pathways. Furthermore, preliminary research suggests the toxicity 25C-NBOMe on the development, heart, and brain health in zebrafish, rats, and Artemia salina, warranting further investigation, particularly concerning potential harm to pregnant women and their fetuses.
Emergency treatment for NBOMe poisoning involves managing acute intoxication symptoms through symptomatic treatments, including benzodiazepines, antipsychotic drugs, and antiarrhythmic agents like beta blockers. Specific interventions are also employed to address rhabdomyolysis, which may lead to critical complications like metabolic acidosis and acute kidney injury.


In the United Kingdom, the categorization of this substance as a Class A drug stems from the inclusion of the N-benzylphenethylamine catch-all clause in the Misuse of Drugs Act 1971.

Similarly, in Sweden, the national public health agency officially classified 25E-NBOMe as a narcotic substance on January 18, 2019.


  • What is 25E-NBOMe?
  • 25E-NBOMe, also known as 2C-E-NBOMe or NBOMe-2C-E, is a chemical derivative derived from the phenethylamine 2C-E. It is known for its potent effects on the 5HT2A receptor, similar to other compounds in the NBOMe family.
  • What are the expected effects of 25E-NBOMe?
  • 25E-NBOMe is reported to produce effects comparable to those of related compounds, such as 25I-NBOMe and 25C-NBOMe. These effects often include hallucinations and other psychoactive experiences.
  • What are the risks associated with 25E-NBOMe use?
  • 25E-NBOMe has been linked to potentially severe risks, including life-threatening toxicity. It is essential to be aware of the possible adverse reactions, including neurotoxic and cardiotoxic effects.
  • How does 25E-NBOMe compare to other substances?
  • 25E-NBOMe shares similarities with other NBOMe compounds regarding their mode of action and potential effects. Understanding these comparisons can help users and researchers better comprehend its potential risks and benefits.
  • What are the legal implications of 25E-NBOMe use?
  • The legal status of 25E-NBOMe varies from country to country. It is essential to stay informed about this substance’s legal framework to avoid any legal repercussions.
  • What precautions should be taken when using 25E-NBOMe?
  • Users should exercise caution when consuming 25E-NBOMe or any related substances. This includes being aware of the proper dosage, understanding potential interactions with other medications, and being conscious of the associated health risks.
  • What are the long-term effects of 25E-NBOMe use?
  • Research on the long-term effects of 25E-NBOMe is still limited. It is crucial to consider the potential long-term impacts on physical and mental health and stay informed about the latest scientific findings in this area.
  • How can one seek help in case of 25E-NBOMe-related emergencies?
  • In case of emergencies or adverse reactions related to 25E-NBOMe use, it is vital to seek immediate medical assistance. Understanding the appropriate steps for emergency intervention can help prevent serious health complications.


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