The market situation for 3-Methoxy-4-methylamphetamine (“MMA”) reflects the broader landscape of designer drugs and research chemicals. This compound is occasionally sold by online vendors and sellers catering to individuals interested in experimental substances.
As a designer drug and research chemical, MMA may attract those seeking novel experiences or exploring uncharted compounds for scientific purposes. Sellers, often operating in a legal grey area, may advertise MMA as a part of their product offerings. However, it’s essential to note that the legality of MMA varies by jurisdiction, and its sale may be subject to legal restrictions in many places.
Potential buyers interested in acquiring MMA should exercise caution and thoroughly research the substance’s legal status in their region. Additionally, buyers should prioritize safety and responsible use, given the limited available data on its effects and potential risks.
In summary, 3-methoxy-4-methylamphetamine occupies a niche within the designer drug and research chemical market, where online vendors may offer it for sale to a select clientele. However, due to legal uncertainties and limited knowledge about its properties, those considering its purchase should proceed cautiously and adhere to local regulations and safety guidelines.
- 1 Summary
- 2 Legal status
- 3 FAQ
- 3.1 1. What is 3-methoxy-4-methylamphetamine (MMA)?
- 3.2 2. Is MMA legal?
- 3.3 3. How was MMA discovered?
- 3.4 4. How is MMA typically consumed?
- 3.5 5. What are the effects of MMA?
- 3.6 6. Is MMA safe to use?
- 3.7 7. Can MMA be detected in drug tests?
- 3.8 8. Are there potential risks associated with MMA use?
- 3.9 9. What should I do if I or someone I know is experiencing adverse effects from MMA use?
- 4 References
3-Methoxy-4-methylamphetamine (MMA) belongs to the entactogen and psychedelic drug categories within the phenethylamine and amphetamine classes. Its origins trace back to its initial synthesis in 1970, with sporadic appearances as a street substance in Italy during the same decade. However, MMA faded into relative obscurity until a resurgence of interest in the early 1990s, when David E. Nichols reassessed it as a non-neurotoxic analogue of MDMA (commonly known as Ecstasy). Since the late 2000s, MMA has gained prominence as a designer drug available for purchase on the internet.
Animal studies have shown that MMA can fully substitute for MDMA and MBDB partially substitute for LSD, but it does not act as a substitute for amphetamine. Additionally, MMA has a notable ability to effectively inhibit serotonin reuptake without inducing serotonergic neurotoxicity in rodents. These findings suggest that MMA operates as a selective serotonin-releasing agent (SSRA) and acts as an agonist for the 5-HT2A receptor. SwissTargetPrediction believes MMA may also exhibit an affinity for receptors such as 5-HT2A, 5-HT1B, D2, and D3, interacting with serotonin, norepinephrine, and dopamine transporters.
At higher doses, typically around 120 mg, MMA produces psychedelic effects akin to substances like DOM.
|CompTox Dashboard (EPA)||DTXSID401007386|
|Chemical and physical data|
|Molar mass||179.263 g·mol−1|
|Legal status||DE: NpSG (Industrial and scientific use only) UK: Class A US: Schedule I (isomer of PMMA)|
1. What is 3-methoxy-4-methylamphetamine (MMA)?
- MMA is a chemical compound classified as an entactogen and psychedelic drug. It falls within the phenethylamine and amphetamine classes and is known for its psychoactive effects.
2. Is MMA legal?
- The legality of MMA varies from country to country and even within different regions. It’s essential to research and understand the legal status of MMA in your specific location before obtaining or using it.
3. How was MMA discovered?
- MMA was first synthesized in 1970 and later surfaced as a street drug in Italy during the same decade. It gained renewed attention in the 1990s when it was reassessed as a potential non-neurotoxic analogue of MDMA.
4. How is MMA typically consumed?
- The consumption methods for MMA may vary, but it is commonly ingested orally. Dosage and administration methods should be cautiously approached due to the limited information on their effects and safety.
5. What are the effects of MMA?
- At typical doses, MMA is reported to induce entactogenic and psychedelic effects, similar to substances like MDMA and LSD. However, the specific effects can vary widely between individuals.
6. Is MMA safe to use?
- The safety of MMA has not been extensively studied, and its long-term effects are largely unknown. Users should exercise extreme caution, adhere to recommended dosages, and prioritize harm reduction practices.
7. Can MMA be detected in drug tests?
- MMA may not be included in standard drug tests, as these tests typically target more common substances. However, specialized tests may be able to detect its presence.
8. Are there potential risks associated with MMA use?
- Like many psychoactive substances, MMA use carries potential risks, including adverse reactions, unknown long-term effects, and legal consequences. Educating yourself and exercising responsible use if you choose to use MMA is crucial.
9. What should I do if I or someone I know is experiencing adverse effects from MMA use?
- If you or someone you know is experiencing adverse effects from MMA use, seek immediate medical attention. Be honest with healthcare professionals about substance use to ensure appropriate care and support.
- In January 1970, a groundbreaking study by Ho BT, McIsaac WM, An R, Tansey LW, Walker KE, Englert LF, and Noel MB was published in the “Journal of Medicinal Chemistry.” This study delved into the realm of amphetamine analogs. The title of the paper was “Analogs of alpha-methylphenethylamine (amphetamine). I. Synthesis and pharmacological activity of some methoxy and/or methyl analogs.” This research marked an important step in understanding the pharmacological properties of various analogs of amphetamine. (DOI: 10.1021/jm00295a007, PMID 5412110)
- In May 1991, Johnson MP, Frescas SP, Oberlender R, and Nichols DE contributed to the field with their research published in the “Journal of Medicinal Chemistry.” Their study, titled “Synthesis and pharmacological examination of 1-(3-methoxy-4-methylphenyl)-2-aminopropane and 5-methoxy-6-methyl-2-aminoindan: similarities to 3,4-(methylenedioxy)methamphetamine (MDMA),” explored the synthesis and pharmacological properties of compounds related to MDMA. (DOI: 10.1021/jm00109a020, PMID 1674539)
- In 1974, de Zorzi C introduced a new hallucinogen, MMA (p-metil-m-metossi anfetamina), in an article titled “Un nuovo allucinogeno: la MMA” published in Zacchia. This publication contributed to the understanding of novel hallucinogenic substances.
- As of 2022, the Swiss Institute of Bioinformatics provides valuable insights into drug-target interactions through “SwissTargetPrediction,” a resource that aids in predicting potential drug targets. This tool has become an invaluable asset in modern pharmacological research. (Source: Swiss Institute of Bioinformatics, Retrieved 2022-12-21)
- The year 1991 witnessed the publication of “Pihkal: A Chemical Love Story” by Shulgin A and Shulgin A. This influential book delves into the chemistry of psychoactive compounds and their effects, offering a unique perspective on the world of mind-altering substances. (ISBN: 0-9630096-0-5)