Empathogens

Summary 5-Methoxymethylone, or 2-A1MP and βk-MMDMA, is a chemical compound classified within the cathinone class. This substance has been available for purchase online as a designer drug. It represents the beta-ketone variant of 5-Methoxy-MDMA. Interestingly, the commonly used names 2-AIMP/2-A1MP do not correspond to the compound’s molecular structure. In contrast to methylone, these two compounds …

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Summary 5-Methylethylone, also known as 5-methyl-βk-MDEA or 5ME, falls within the amphetamine, phenethylamine, and cathinone chemical classes, making it a versatile compound with empathogenic, stimulant, and psychedelic properties. This substance shares structural similarities with ethylone, another designer drug. However, limited information is available regarding the pharmacological characteristics, metabolism, and potential toxicity of 5-methylethylone despite its …

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Summary 5-Methyl-3,4-methylenedioxyamphetamine (5-Methyl-MDA) is a designer drug belonging to the amphetamine class, known for its entactogenic and psychedelic properties. It is characterized by a methyl group on the amphetamine ring, making it a ring-methylated homolog of MDA and a structural isomer of MDMA. Identifiers IUPAC name CAS Number 749191-14-8 204916-89-2 (HCl) PubChem CID 10012829 ChemSpider 8188403  …

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Summary Pentylone, also known as β-Keto-Methyl​benzo​dioxolyl​pentanamine, βk-Methyl-K, βk-MBDP, methyl​enedioxy​pentedrone, or 1‐(3,4‐methylenedioxyphenyl)‐2‐(methylamino)pentan‐1‐one, is a stimulant that was developed during the 1960s. This compound falls under the category of substituted cathinones, which are a type of substituted phenethylamines.Pentylone has been detected in specific samples of powders that were marketed as “NRG-1.” These samples sometimes contained varying mixtures …

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Summary Eutylone, also referred to as β-keto-1,3-benzodioxolyl-N-ethylbutanamine, bk-EBDB, and N-ethylbutylone, is a synthetic stimulant and empathogenic substance that originated in the 1960s. It is categorized as a designer drug, not naturally occurring, and was first reported to the EMCDDA in 2014. Eutylone gained widespread international use between 2019 and 2020, particularly following the prohibition of …

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Summary 3,4-Methylenedioxy-N-hydroxyamphetamine, MDOH or MDH, belongs to the entactogen, psychedelic, and stimulant categories within the phenethylamine and amphetamine chemical families. This compound serves as the N-hydroxy counterpart of MDA and the N-desmethyl analog of MDHMA. Alexander Shulgin carried out the initial synthesis and evaluation of MDOH.In his influential book, “PiHKAL” (Phenethylamines I Have Known And …

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Summary N-Methyl-1,3-benzodioxolylpentanamine (MBDP; also referred to as Methyl-K, UWA-091), scientifically known as 3,4-methylenedioxy-α-propyl-N-methylphenethylamine, is a psychoactive compound belonging to the phenethylamine chemical class. This substance is the N-methyl counterpart to 1,3-benzodioxolylpentanamine (BDP; K). Methyl-K synthesis can be credited to Alexander Shulgin, often affectionately called “Sasha” Shulgin. Shulgin’s comprehensive work, PiHKAL (“Phenethylamines I Have Known And …

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Summary Ethylone, or 3,4-methylenedioxy-N-ethylcathinone (MDEC or βk-MDEA), is a recreational designer drug with classifications in the entactogen, stimulant, and psychedelic categories. It belongs to the phenethylamine, amphetamine, and cathinone chemical classes. Ethylone serves as the β-keto analog of MDEA, commonly known as “Eve.” Notably, it has a relatively brief history of human use and is …

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Summary Ethylbenzodioxolylbutanamine (EBDB), also known as Ethyl-J, is a relatively lesser-known substance known for its entactogenic, stimulant, and psychedelic properties. It serves as the N-ethyl counterpart to benzodioxylbutanamine (BDB), often referred to as “J,” and the α-ethyl companion to methylenedioxymethamphetamine (MDEA), commonly known as “Eve.”Alexander Shulgin first carried out the synthesis of EBDB. In his …

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