Opioids

Methoxyacetylfentanyl

Summary Methoxyacetylfentanyl, often referred to as MAF, is an opioid analgesic. It is structurally related to fentanyl and has been available for purchase on the internet as a designer drug. Identifiers IUPAC name CAS Number 101345-67-9 PubChem CID 968688 ChemSpider 838859 UNII U7IAB3Z3V4 ChEMBL ChEMBL1740467 Chemical and physical data Formula C22H28N2O2 Molar mass 352.47 g·mol−1 Side …

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Isotonitazene

Summary Isotonitazene is an opioid analgesic drug derived from benzimidazole, and it shares a relationship with etonitazene. Marketed as a designer drug, it exhibits approximately half the potency of etonitazene in animal studies. However, it’s likely even less potent in humans, mirroring the pattern observed with etonitazene (which was approximately 1000 times as potent as …

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Flunitazene

Summary Flunitazene, also known as Fluonitazene, is a benzimidazole-derived compound recognized for its opioid properties. It was initially formulated in the 1950s as part of the scientific exploration that eventually yielded more widely recognized substances like etonitazene. Despite being one of the less potent derivatives in its class, having roughly equivalent potency to morphine, Flunitazene …

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Etonitazepyne

Summary Etonitazepyne, also known as N-Pyrrolidino Etonitazene, is a benzimidazole-derived compound renowned for its powerful opioid properties. It has been illicitly marketed online as a designer drug and has been associated with a significant number of overdose incidents. Identifiers IUPAC name PubChem CID 155804760 ChemSpider 103835282 UNII 8HY67JQ9ZH Chemical and physical data Formula C22H26N4O3 Molar …

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Etodesnitazene

Summary Etodesnitazene, also known as Desnitroetonitazene, Etazen, Etazene, or Etazone, is an opioid analgesic drug derived from benzimidazole. Its origins date back to the late 1950s, when it was developed alongside etonitazene and a range of related derivatives. While Etodesnitazene is significantly less potent than etonitazene itself, it still exhibits about 70 times the potency …

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2,2′-Difluorofentanyl

Summary 2,2′-Difluorofentanyl is a synthetic opioid analgesic, closely related to fentanyl, and has gained notoriety as a designer drug. Identifiers IUPAC name CAS Number 2748343-87-3 PubChem CID 137700285 UNII B61QTX2SWO Chemical and physical data Formula C22H26F2N2O Molar mass 372.460 g·mol−1 Side effects The side effects of fentanyl analogs mirror those of fentanyl itself, encompassing symptoms such …

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Dipyanone

Summary Dipyanone, an opioid analgesic, emerged as a designer drug and was initially detected in Germany in 2021. This compound shares close structural similarities with medically approved opioids like methadone, dipipanone, and phenadoxone, although it exhibits slightly less potency. Identifiers IUPAC name CAS Number 60996-94-3  UNII P8UN8D5PUN Chemical and physical data Formula C23H29NO Molar mass …

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Diphenpipenol

Summary Diphenpipenol, a synthetic opioid analgesic, emerged in the 1970s through the innovative work of Dainippon Pharmaceutical Co.Structurally, it belongs to the class of 1-substituted-4-(1,2-diphenylethyl)piperazine derivatives, sharing similarities with compounds like MT-45 and AD-1211. Notably, within this group, diphenpipenol stands out as the most potent compound. In animal studies, the (S) enantiomer, in particular, exhibits …

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Desmethylmoramide

Sumamry Desmethylmoramide, known by its INN (International Nonproprietary Name), is an opioid analgesic with a connection to dextromoramide, the active (+)-isomer of moramide. It was synthesized and characterized during the late 1950s but did not enter the market. Identifiers CAS Number 1767-88-0  3D model (JSmol) Interactive image ChEMBL ChEMBL2106152 ChemSpider 178501 PubChemCID 206005 UNII 9B1Z1V29C3  …

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Desmethylprodine

Summary Desmethylprodine, also known as MPPP or Ro 2-0718, is an opioid analgesic initially developed in the 1940s by scientists at Hoffmann-La Roche. In the United States, the Drug Enforcement Administration (DEA) has classified Desmethylprodine as a Schedule I substance, which denotes its controlled and illegal status. Notably, it is an analog of pethidine (meperidine), …

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