Summary Valerylfentanyl, an opioid analgesic analogue of fentanyl, has made appearances as a designer drug in online markets. Despite being relatively uncommon in illicit trade, limited information is available about this substance. It is generally thought to possess intermediate potency, with greater strength compared to benzyl fentanyl but lower power than butyrfentanyl. A study found …
Summary U-48800 is an opioid analgesic that has found its way into the designer drug market. Differing from U-47700, it primarily functions as a kappa opioid receptor agonist with only moderate affinity for the mu-opioid receptor. Despite this distinction, it has emerged in the realm of recreational drug use, sometimes forming part of drug combinations. …
Summary Tetrahydrofuranylfentanyl is a designer drug that emerged in Europe in late 2016. It is classified as an opioid analgesic and is structurally related to fentanyl. Identifiers IUPAC name CAS Number 2142571-01-3 PubChem CID 137332293 UNII Z3UD65Z8B2 Chemical and physical data Formula C24H30N2O2 Molar mass 378.516 g·mol−1 Side effects The side effects associated with fentanyl analogues …
Summary Protonitazene is a benzimidazole-derived compound recognized for its potent opioid properties. Since 2019, it has gained prominence as a designer drug available on the internet, being detected in multiple European nations, Canada, the USA, and Australia. However, it has also been associated with numerous instances of drug overdoses, leading to its classification as a …
Summary Piperidylthiambutene, also known as Piperidinohton, belongs to the thiambutene family and is a synthetic opioid analgesic drug. It shares a similar potency to morphine. Unlike fentanyl, its analogues, and previously known synthetic opioids, Piperidylthiambutene exhibits a unique chemical structure.It’s important to note that in certain countries, including the United States, Australia, and New Zealand …
Summary Desmetramadol, also known by its International Nonproprietary Name (INN) as O-desmethyltramadol (O-DSMT), is an opioid analgesic and serves as the primary active metabolite of tramadol. Tramadol undergoes demethylation via the liver enzyme CYP2D6, leading to the formation of desmetramadol, a process akin to the way codeine is metabolized. Consequently, just as variations in the …
Summary Nortilidine represents the primary active metabolite derived from tilidine, arising through liver demethylation. The racemic form of nortilidine exhibits opioid analgesic effects that are approximately equivalent in potency to morphine. Notably, the (1R,2S) isomer of nortilidine displays NMDA antagonist activity. Furthermore, this compound also functions as a dopamine reuptake inhibitor. Variants of nortilidine include …
Summary MT-45 (also known as IC-6) is an opioid analgesic medication that was initially created in the 1970s by Dainippon Pharmaceutical Co. Its chemical structure is that of a 1-substituted-4-(1,2-phenylmethyl) piperazine derivative, setting it apart from the majority of other opioid drugs. In its racemic form, MT-45 possesses approximately 80% of the potency of morphine, …
Summary Metonitazene, an analgesic compound closely related to etonitazene, was initially reported in 1957. When administered through central routes, it exhibits an astounding potency, approximately 100 times greater than morphine. However, when taken orally, its strength decreases to around 10 times that of morphine.Its effects mirror those of other opioids, such as fentanyl and heroin, …
Summary Metodesnitazene, also recognized as Metazene, belongs to the class of benzimidazole derivatives, exhibiting opioid-like properties. However, in contrast to closely related substances like metonitazene and etodesnitazene, which display significantly higher potency, metodesnitazene demonstrates a level of power in animal studies that is roughly equivalent to morphine. In December 2021, the United States Drug Enforcement …
