Summary 5F-PCN, also identified as 5F-MN-21, belongs to the category of azaindole-based synthetic cannabinoids. It is presumed to possess potent agonistic effects on the CB1 receptor and has found its way into online markets as a designer drug. Notably, it shares a close chemical relationship with NNE1.An intriguing aspect to consider is the metabolic processes …
summary 5F-AB-FUPPYCA, or AZ-037, is a synthetic cannabinoid rooted in the pyrazole structure. It is presumed to act as an agonist targeting the CB1 receptor and has gained popularity as a designer drug available for purchase online. Notably, it came into the spotlight when the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) identified …
Summary 3-(4-Hydroxymethylbenzoyl)-1-pentylindole is classified as a synthetic cannabinoid, and there are plans to include it in Schedule I-N in Poland. This compound was first reported to the EMCDDA and Europol in 2010 by the provisions of the European Council Decision 2005/387/JHA dated 10 May 2005, which pertains to the exchange of information, risk assessment, and …
Summary CP 55,244, a chemical compound, serves as a potent agonist of cannabinoid receptors. Renowned for its analgesic properties, it finds significant utility in scientific investigations. With an extraordinary potency, CP 55,244 emerges as an extremely formidable CB1 full agonist, boasting a remarkable Ki of 0.21 nM, surpassing the commonly employed full agonist HU-210. Identifiers …
Summary CP 55,940, a synthetic cannabinoid, replicates the effects of naturally found THC, one of the active compounds present in cannabis. This compound was originally developed by Pfizer in 1974 but was never brought to the market. Today, it is a valuable research tool for investigating the endocannabinoid system. Identifiers IUPAC name CAS Number 83002-04-4 …
Summary CP 47,497, also known as (C7)-CP 47,497, is a cannabinoid receptor agonist medication initially crafted by Pfizer during the 1980s. This compound, valued for its analgesic properties, is crucial in scientific investigations. Notably, CP 47,497 is a robust CB1 agonist with a Kd value of 2.1 nM. Identifiers IUPAC name CAS Number (1S,3R): 70434-82-1 PubChem …
Summary HU-308, referred to as onternabez, PPP-003, and ARDS-003, represents a drug derived from cannabidiol (CBD) and functions as a potent cannabinoid agonist. Notably, HU-308 exhibits a remarkable degree of selectivity, primarily targeting the cannabinoid-2 receptor (CB2 receptor) subtype. Its selectivity for the CB2 receptor surpasses that of the CB1 receptor by over 5,000 times.The …
Sumamry Ajulemic acid, also known as DMH-D8-THC-11-OIC, AB-III-56, HU-239, IP-751, CPL 7075, CT-3, JBT-101, Anabasum, Resunab, or Lenabasum, is a synthetic cannabinoid that exhibits anti-fibrotic and anti-inflammatory properties in pre-clinical research without inducing a subjective “high.” While its design was inspired by delta-9-THC metabolites, such as delta-9-THC-11-oic acid, academic acid is an analog of delta-8-THC …
Summary AM-087, a member of the AM cannabinoid series, is an analgesic medication functioning as a cannabinoid agonist. Derived from Δ8-THC, it features a substitution on the 3-position side chain. AM-087 stands out as a potent CB1 agonist, boasting a Ki value of 0.43 nM, rendering it approximately 100 times more potent than THC. This …
Summary HU-243, also known as AM-4056, is a synthetic cannabinoid compound representing the single enantiomer of the hydrogenated derivative derived from the widely referenced agonist HU-210. It serves as a methylene homolog of canbisol. Remarkably, HU-243 displays robust agonistic activity at both the CB1 and CB2 receptors, boasting an impressive binding affinity of 0.041 nM …
