Summary RCS-8, also known as 1-(2-cyclohexyl ethyl)-3-(2-methoxyphenylacetyl)indole and referred to as SR-18 and BTM-8, is a synthetic cannabinoid that has been identified as an ingredient in “herbal” synthetic cannabis mixtures. Structurally, it can be characterized as an analog of JWH-250, where the 1-pentyl group is replaced by 1-(2-cyclohexylethyl). As a result of this structural modification, …
Summary JWH-251, scientifically referred to as 1-pentyl-3-(2-methylphenylacetyl)indole, belongs to the phenylacetylindole family, characterized as a synthetic cannabinoid. It acts as a cannabinoid agonist, exhibiting approximately five times more selectivity for CB1 receptors, with a Ki of 29 nM, compared to CB2 receptors, with a Ki of 146 nM. Similar to its counterparts, such as the …
Summary JWH-250, scientifically known as 1-pentyl-3-(2-methoxyphenylacetyl)indole, is a member of the phenylacetylindole family recognized for its analgesic properties. This chemical compound operates as a cannabinoid agonist, engaging with CB1 and CB2 receptors, featuring a Ki of approximately 11 nM at CB1 and 33 nM at CB2. It’s noteworthy that JWH-250 distinguishes itself from many older …
Summary JWH-249, also known as 1-pentyl-3-(2-bromophenylacetyl)indole, is a synthetic cannabinoid belonging to the phenylacetylindole family. It operates as a cannabinoid agonist with approximately 2.4 times higher selectivity for CB1 receptors, having a Ki of roughly 8.4 ± 1.8 nM, compared to CB2 receptors, where its Ki is around 20 ± 2 nM. Much like its …
Summary JWH-203, also known as 1-pentyl-3-(2-chlorophenylacetyl)indole, is a member of the phenylacetylindole family and serves as an analgesic chemical. This compound functions as a cannabinoid agonist, demonstrating nearly equal affinity for CB1 and CB2 receptors, with a Ki of approximately 8.0 nM at CB1 and 7.0 nM at CB2. Originally named after its discoverer, John …
Summary JWH-167, also known as 1-pentyl-3-(phenylacetyl)indole, is a synthetic cannabinoid belonging to the phenylacetylindole family. This compound acts as a cannabinoid agonist with approximately 1.75 times higher selectivity for CB1 receptors, exhibiting a Ki of about 90 nM ± 17 and around 159 nM ± 14 at CB2 receptors. Notably, JWH-167 shares structural similarities with …
Summary NM-2201, alternatively recognized as CBL-2201, belongs to the family of indole-based synthetic cannabinoids. It is theorized to exhibit analogous characteristics to its closely related counterparts, 5F-PB-22 and NNE1. These compounds are categorized as full agonists, demonstrating an indiscriminate binding affinity to CB1 and CB2 receptors at a low nanomolar level. Identifiers IUPAC name CAS …
Summary NE-CHMIMO (also known as CHM-018) is a synthetic cannabinoid with an indole base believed to act as a potent agonist of the CB1 receptor. It has gained prominence as a designer drug available for purchase online. NE-CHMIMO distinguishes itself by having a 1-cyclohexyl methyl group instead of the 1-pentyl group found in the first-generation …
Summary MAM-2201, also known as 4′-methyl-AM-2201 or 5″-fluoro-JWH-122 is believed to act as a potent agonist for cannabinoid receptors. This compound remained undocumented in scientific or patent literature until laboratories in the Netherlands and Germany first discovered it in June 2011 when used as an ingredient in synthetic cannabis smoking blends. Like RCS-4 and AB-001, …
Summary JWH-424 is a member of the naphthoylindole family, characterized by its role as a cannabinoid agonist targeting both the CB1 and CB2 receptors. However, it demonstrates moderate selectivity for the CB2 receptor, with a Ki value of 5.44nM at CB2 in contrast to 20.9 nM at CB1. The heavier 8-iodo analog of this compound …
