Summary Flubromazolam, also known as JYI-73, belongs to the class of triazolobenzodiazepines (TBZDs), which are derivatives of benzodiazepines (BZDs). This compound has gained a reputation for its remarkably high potency. Concerns have emerged regarding the safety of substances like clonazolam and flubromazolam, mainly due to their potential to induce profound sedation and amnesia, even at …
Summary Flubromazepam initially synthesised in 1960 but never officially marketed or extensively studied, resurfaced in late 2012 within the grey market as an emerging designer drug. This benzodiazepine derivative gained renewed attention and interest.Structurally, it bears a resemblance to phenazepam, with the notable substitution of a chlorine atom for a fluorine atom.It’s worth noting that …
Summary Flualprazolam is a tranquillizing agent belonging to the triazolobenzodiazepine (TBZD) class, characterized by benzodiazepines (BZDs) fused with a triazole ring. Its initial synthesis took place in 1976 but remained unmarked. This compound can be viewed as the triazole counterpart of fludiazepam and has gained popularity as a designer drug. It was officially identified as …
Summary Diazepam (also referred to as chlorodiazepam and 2′-chloro-diazepam) is a benzodiazepine compound and serves as a functional analogue of diazepam. This chemical entity was initially synthesized by Leo Sternbach and his research team at Hoffman-La Roche in 1960. Despite its origins, diazepam has not obtained approval for clinical use as a medication and is …
Summary Desmethylflunitrazepam, which is also referred to as norflunitrazepam, Ro05-4435, and fonazepam, is a benzodiazepine compound. This substance is a metabolite of flunitrazepam and has been made available for purchase online as a designer drug. It exhibits a notable IC50 value of 1.499 nM for its interaction with the GABAA receptor. Identifiers IUPAC name CAS …
Summary Cloniprazepam, a benzodiazepine derivative, serves as a prodrug for clonazepam, generating 7-aminoclonazepam and various other metabolites.Among these minor metabolites are 3-hydroxyclonazepam, 6-hydroxyclonazepam, 3-hydroxycloniprazepam, and ketocloniprazepam, which features a ketone group formed in place of the 3-hydroxy group.Cloniprazepam is categorized as a designer drug and falls under the umbrella of “new psychoactive substances” (NPS). Towards …
Summary Clonazolam, also referred to as clonitrazolam, belongs to the triazolobenzodiazepine (TBZD) class, a category combining traditional benzodiazepines (BZDs) with a triazole ring. The existing knowledge about its effects and metabolic processes is limited, and clonazolam is available for purchase online as a designer drug. The synthesis of clonazolam was first documented in 1971, and …
Summary Bromazolam (also known as XLI-268) is a triazolobenzodiazepine (TBZD) compound initially synthesized in 1976 but never brought to the pharmaceutical market. It gained recognition as a designer drug and was first conclusively identified by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) in Sweden in 2016. As the bromo analogue of alprazolam, …
Summary Adinazolam, marketed under the brand name Deracyn, is a tranquilizer belonging to the triazolobenzodiazepine (TBZD) class. This class combines traditional benzodiazepines (BZDs) with a triazole ring. Adinazolam is known for its anxiolytic, anticonvulsant, sedative, and antidepressant properties. The drug’s development can be credited to Jackson B. Hester, who aimed to enhance the antidepressant effects …
Summary 3-Hydroxyphenazepam is a benzodiazepine renowned for its hypnotic, sedative, anxiolytic, and anticonvulsant attributes. Notably, it serves as an active metabolite of phenazepam and also acts as the active metabolite of the benzodiazepine prodrug cinazepam. In comparison to phenazepam, 3-hydroxyphenazepam exhibits reduced myorelaxant effects but remains largely on par in most other aspects.Much like its …
