Summary Dizocilpine, also known as MK-801, is a compound discovered by Merck in 1982, functioning as a pore blocker for the N-Methyl-D-aspartate (NMDA) receptor, which is a vital glutamate receptor in the brain. Glutamate serves as the primary excitatory neurotransmitter in the brain.Under normal conditions, the NMDA receptor channel is blocked by a magnesium ion …
Summary Fluorolintane, commonly referred to as 2-FPPP and 2-F-DPPy, is a dissociative anaesthetic substance that has been available for purchase online as a designer drug.These compounds, including Fluorolintane, belong to the group of diarylethylamines and exhibit properties as antagonists of the NMDA receptor. They have been examined in laboratory settings as prospective remedies for conditions …
Summary Ephenidine, also recognized under the aliases NEDPA and EPE, is categorized as a dissociative anaesthetic with a history of availability as a designer drug via online markets. While its legality status varies globally, certain nations have prohibited it due to its structural resemblance to the banned opioid, lefetamine. Nevertheless, Ephenidine continues to be commercially …
Summary Diphenidine, also known as 1,2-DEP, DPD, or DND, is a dissociative anesthetic that has been distributed as a designer drug. The synthesis of piperidine dates back to 1924 when a method employing a Bruylants reaction was first reported, a process that would later be utilized to discover phencyclidine in 1956. Following the 2013 ban …
Summary N-Ethylnorketamine, also known as eth ketamine, NENK, or 2-Cl-2′-Oxo-PCE, is a designer drug believed to share characteristics with ketamine. Ketamine is a dissociative anesthetic drug recognized for its hallucinogenic and sedative effects. N-Ethylnorketamine emerged in online markets around September 2012 and has been detected in drug samples seized by analytical laboratories in the UK …
Summary Methoxyketamine, also known as 2-MeO-2-deschloroketamine, is a designer drug belonging to the arylcyclohexylamine class. It was initially documented in 1963. This compound serves as an analog to ketamine, with the chlorine atom replaced by a methoxy group. Its synthesis, involving the rearrangement of an amino ketone, has been detailed in reports.Being classified as an …
Summary MXiPr, also known as Methoxisopropamine, Isopropyloxetamine, and Isopropyxetamine, is a recreational designer drug celebrated for its dissociative effects. It falls under the arylcyclohexylamine derivative category, sharing kinship with well-known substances like ketamine and methoxetamine. This compound was initially detected in Slovenia in December 2020 and became subject to legal restrictions, being prohibited in Hungary …
Summary Methoxpropamine, also known as MXPr and 2-Oxo-3′-methoxy-PCPr, falls within the category of dissociative anesthetic drugs belonging to the arylcyclohexylamine class. It functions as an NMDA receptor antagonist. Methoxpropamine shares structural similarities with other substances like methoxetamine and PCPr. This compound has been marketed online as a designer drug and was initially detected in Denmark …
Summary Methoxetamine, which is also recognized under names such as 3-MeO-2′-Oxo-PCM, MXM, and MMXE, belongs to the arylcyclohexylamine class of dissociative anesthetics. It shares close structural similarities with substances like methoxetamine and methoxetamine. Methoxetamine has gained popularity as a designer drug available for purchase on the internet. Identifiers IUPAC name CAS Number 1781829-56-8 PubChem CID …
Summary Methoxetamine, often abbreviated as MXE, is a dissociative hallucinogenic substance that has been distributed as a designer drug. What sets it apart from many dissociatives, such as ketamine and phencyclidine (PCP), developed initially as pharmaceutical anesthetics, is that MXE was intentionally crafted to enhance the antidepressant effects of ketamine.MXE belongs to the class of …
