Opioids

Crotonylfentanyl

Summary Crotonylfentanyl is an opioid pain reliever, structurally related to fentanyl, and a structural isomer of cyclopropylfentanyl. It has been available on the internet as a designer drug. In December 2019, the United Nations Office on Drugs and Crime (UNODC) introduced scheduling recommendations to classify crotonylfentanyl as a Schedule I substance. Identifiers IUPAC name CAS …

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Cyclopropylfentanyl

Summary Cyclopropyl fentanyl is an opioid pain reliever, structurally similar to fentanyl, and has been distributed as a designer drug. Between June and December 2017, European countries reported a total of 78 fatalities linked to cyclopropyl fentanyl, with analytical confirmation from post-mortem samples. An additional 115 deaths associated with cyclopropyl fentanyl use were reported in …

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Cyclopentylfentanyl

Summary Cyclopentylfentanyl is an opioid pain reliever structurally related to fentanyl, which has been available on the internet as a designer drug, primarily in Sweden and other Nordic countries. Identifiers IUPAC name CAS Number 2088918-01-6 PubChem CID 126682248 ChemSpider 81367208 UNII 79NY29L78C Chemical and physical data Formula C25H32N2O Molar mass 376.544 g·mol−1 Side effects The side …

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Clonitazene

Summary Clonitazene is an opioid pain reliever that boasts nearly triple the potency of morphine. This compound shares a kinship with etonitazene, an opioid with notably greater power. Clonitazene is not commercially available at present. Regarded as a controlled substance, it holds a Schedule I classification in the United States as a Narcotic controlled substance, …

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Butonitazene

Summary Butonitazene, categorized as a benzimidazole-derived substance with opioid properties, has been available on the internet as a designer drug. In its natural form, it exhibits moderate potency when compared to its chemical counterparts. It is commonly found as part of blends containing various substances rather than in its unadulterated state. Nevertheless, it remains significantly …

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Brorphine

Summary Brorphine is a piperidine-based opioid analgesic compound that first came to scientific attention in 2018. Initially, it was explored in research focused on functionally biased opioid compounds, with the aim of developing safer analgesics that induce less respiratory depression compared to conventional opioids. While it was initially reported as highly personal, more recent studies …

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Bromadoline

Summary Bromadoline, also known as U-47931E, is a μ-opioid receptor-selective opioid analgesic created by Upjohn in the 1970s. It falls within the range of potency between codeine and morphine, with slight superiority to pentazocine. Bromadoline shares a chemical relationship with AH-7921 and U-47700. Identifiers IUPAC name CAS Number 2418521-61-4  67579-24-2 (mixture of trans isomers) PubChem …

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Butyrfentanyl

Summary Butyrfentanyl, also known as butyrylfentanyl, is a potent, short-acting synthetic opioid analgesic. It serves as an analog of fentanyl, boasting roughly one-quarter of its potency. The initial reference to this compound can be traced back to a document published by The College on Problems of Drug Dependence, where it is denoted as “N-butyramide fentanyl …

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BDPC

Summary BDPC, also known as bromadol, is a highly potent narcotic analgesic characterized by its unique arylcyclohexylamine chemical structure. This compound was initially developed by Daniel Lednicer at Upjohn during the 1970s.Early investigations suggested that BDPC exhibited a staggering potency, estimated to be approximately 10,000 times stronger than morphine in animal models. However, subsequent studies …

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AP-238

Summary AP-238 is an opioid-designer drug sharing chemical kinship with compounds like azaprocin and bucinnazine, exhibiting a potency level akin to that of morphine. Originating in Italy during the 1960s, it remained unmarketed yet emerged on the underground market approximately in 2020, making notable appearances in both Slovenia and the United States. Identifiers IUPAC name …

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