Summary HU-308, referred to as onternabez, PPP-003, and ARDS-003, represents a drug derived from cannabidiol (CBD) and functions as a potent cannabinoid agonist. Notably, HU-308 exhibits a remarkable degree of selectivity, primarily targeting the cannabinoid-2 receptor (CB2 receptor) subtype. Its selectivity for the CB2 receptor surpasses that of the CB1 receptor by over 5,000 times.The …
Sumamry Ajulemic acid, also known as DMH-D8-THC-11-OIC, AB-III-56, HU-239, IP-751, CPL 7075, CT-3, JBT-101, Anabasum, Resunab, or Lenabasum, is a synthetic cannabinoid that exhibits anti-fibrotic and anti-inflammatory properties in pre-clinical research without inducing a subjective “high.” While its design was inspired by delta-9-THC metabolites, such as delta-9-THC-11-oic acid, academic acid is an analog of delta-8-THC …
Summary AM-087, a member of the AM cannabinoid series, is an analgesic medication functioning as a cannabinoid agonist. Derived from Δ8-THC, it features a substitution on the 3-position side chain. AM-087 stands out as a potent CB1 agonist, boasting a Ki value of 0.43 nM, rendering it approximately 100 times more potent than THC. This …
Summary HU-243, also known as AM-4056, is a synthetic cannabinoid compound representing the single enantiomer of the hydrogenated derivative derived from the widely referenced agonist HU-210. It serves as a methylene homolog of canbisol. Remarkably, HU-243 displays robust agonistic activity at both the CB1 and CB2 receptors, boasting an impressive binding affinity of 0.041 nM …
Summary JWH-133, also known as Dimethylbutyl-deoxy-Delta-8-THC, stands out as a potent and highly selective agonist of the CB2 receptor, exhibiting a remarkable Ki value of 3.4nM and an impressive selectivity of approximately 200 times for CB2 over CB1 receptors. This compound owes its name to the pioneering researcher John W. Huffman.In scientific literature, JWH-133 has …
Summary JWH-051 is an analgesic medication that functions as a cannabinoid agonist. Its chemical structure closely resembles the potent cannabinoid agonist HU-210, with the sole distinction being the absence of the hydroxyl group at position 1 of the aromatic ring. This compound was first identified and named in honor of John W. Huffman.JWH-051 maintains a …
Summary HU-210, a synthetic cannabinoid, was initially synthesized in 1988 by a research team led by Raphael Mechoulam at the Hebrew University. It boasts an astonishing potency, ranging from 100 to 800 times greater than naturally occurring THC found in cannabis. Additionally, HU-210 exhibits a significantly prolonged duration of action. In terms of its receptor …
Summary Dimethylheptylpyran, also known as DMHP, 3-(1,2-dimethylheptyl)-Δ6a(10a)-THC, 1,2-dimethylheptyl-Δ3-THC, A-40824, or EA-2233, represents a synthetic analogue of THC. This compound was first developed in 1949 as part of scientific efforts aimed at unraveling the structure of Δ9-THC, one of the primary active constituents found in Cannabis. DMHP presents itself as a pale yellow, viscous oil that …
Summary Parahexyl, also known as Synhexyl or n-hexyl-Δ3-THC, is a synthetic counterpart to THC (tetrahydrocannabinol). It was developed in 1941 as part of efforts to decipher the chemical structure of Δ9-THC, one of the primary active compounds found in cannabis.Parahexyl closely resembles THC in terms of both its structure and its effects, with the only …
Summary Nabilone, marketed under the trade name Cesamet and other brands, is a synthetic cannabinoid recognized for its therapeutic applications as an antiemetic and as a supplementary analgesic in managing neuropathic pain. This compound emulates tetrahydrocannabinol (THC), the primary psychoactive component naturally found in the Cannabis plant. In the United States, the Food and Drug …
