Summary ADB-CHMINACA, also recognized as MAB-CHMINACA, belongs to the class of indazole-based synthetic cannabinoids. Initially designed by Pfizer in 2009 for its potential as an analgesic medication, it stands out as a robust agonist of the CB1 receptor, boasting an impressive binding affinity with a Ki value as low as 0.289 nM. This compound gained …
Summary ADB-BINACA is a synthetic cannabinoid designer drug that has been identified as a component in certain synthetic cannabis formulations. Initially conceived by Pfizer for its potential analgesic properties, this compound is a robust agonist for the CB1 receptor, boasting an impressive binding affinity (Ki) of 0.33 nM and an EC50 of 14.7 nM. Identifiers …
Summary Adamantyl-THPINACA, often abbreviated as ATHPINACA or AD-THPINACA, is a synthetic cannabinoid compound based on the indazole structure. Its presence was initially documented in Slovenia in January 2015, and it exists in two distinct isomeric forms: the 1-adamantyl and 2-adamantyl isomers, identified as SGT-40 and SGT-194, respectively, a differentiation that can be established through GC-EI-MS …
Summary AB-PINACA, originally detected as an ingredient in synthetic cannabis products in Japan back in 2012, has a notable history. Initially, it was formulated by Pfizer in 2009 with the intent of serving as an analgesic medication.This compound exhibits a strong affinity for the CB1 receptor (Ki = 2.87 nM, EC50 = 1.2 nM) and …
Summary AB-CHMINACA is a synthetic cannabinoid rooted in the indazole structure. It is a robust agonist for the CB1 receptor (Ki = 0.78 nM) and CB2 receptor (Ki = 0.45 nM). In rat discrimination studies, AB-CHMINACA demonstrates a complete substitution for Δ9-THC, surpassing its potency by 16. Following the pattern observed in other cannabinoids of …
Summary 5F-EMB-PINACA, alternatively referred to as EMB-5F-PINACA by the naming conventions of synthetic cannabinoids outlined by the EMCCDA, and also known as 5F-AEB, is a synthetic cannabinoid derived from the indazole-3-carboxamide family. This compound has been marketed as a designer drug and is readily available for purchase online.The EMCDDA brought attention to 5F-EMB-PINACA when it …
Summary 5F-CUMYL-PINACA, also recognized as SGT-25 and occasionally marketed in e-cigarette form as C-Liquid, is a synthetic cannabinoid with an indazole-3-carboxamide base.This compound acts as a potent agonist for cannabinoid receptors. According to the initial patent, it displayed approximately fourfold selectivity for CB1 receptors, boasting an EC50 of <0.1 nM for human CB1 receptors and …
Summary 5F-EMB-PINACA, alternatively recognized as EMB-5F-PINACA by the EMCCDA’s nomenclature for synthetic cannabinoids and also referred to as 5F-AEB is a member of the indazole-3-carboxamide family of synthetic cannabinoids. This compound has been marketed on the internet as a designer drug.In April 2015, the EMCDDA initially documented its existence as part of a seizure in …
Summary 5F-CUMYL-PINACA also recognized as SGT-25 and occasionally marketed in e-cigarette form as C-Liquid, belongs to the category of indazole-3-carboxamide-based synthetic cannabinoids. It exerts its action as a potent agonist on cannabinoid receptors, with the original patent asserting approximately fourfold selectivity for CB1. It exhibits an EC50 of less than 0.1 nM for human CB1 …
Summary 5F-APINACA, also recognized as 5F-AKB-48 or 5F-AKB48, is a synthetic cannabinoid based on the indazole structure and has been available for purchase as a designer drug online. In terms of its chemical structure, it closely resembles cannabinoid compounds outlined in patent WO 2003/035005, differing by the presence of a 5-fluorophenyl chain on the indazole …
