Summary JWH-019, a member of the naphthoylindole family, is recognized as an analgesic compound acting as a cannabinoid agonist at both CB1 and CB2 receptors. Notably, it is the N-hexyl homolog of the known synthetic cannabinoid JWH-018. In contrast to the butyl homolog, JWH-073, which exhibits significantly lower potency than JWH-018, the hexyl homolog, JWH-019, …
Summary JWH-015, a member of the naphthoylindole family, functions as a cannabinoid agonist with subtype selectivity. Notably, it exhibits a high affinity for CB2 receptors, with a binding relationship of 13.8 nM, while its affinity for CB1 receptors is notably lower at 383 nM. This results in JWH-015 binding nearly 28 times more strongly to …
Summary JWH-007, a member of the naphthoylindole family, is a chemical compound primarily recognized for its analgesic properties. It functions as a cannabinoid agonist, engaging both CB1 and CB2 receptors. This compound was initially documented in 1994, and its discovery is attributed to a group led by the renowned cannabinoid chemist John W. Huffman.This compound …
Summary FUB-JWH-018, sometimes referred to as FUB-018, is a synthetic cannabinoid derived from naphthoylindole. It can be described as a molecular hybrid, combining elements of JWH-018 and AB-FUBICA or ADB-FUBICA. Identifiers IUPAC name CAS Number 2365471-45-8 ChemSpider 34450892 UNII U0Z5KO073G Chemical and physical data Formula C26H18FNO Molar mass 379.434 g·mol−1 Legal status In the United States, …
Summary EAM-2201, also known as 4′-ethyl-AM-2201, 5″-fluoro-JWH-210, or SGT-14, is a substance believed to function as a potent agonist for cannabinoid receptors. This compound was not documented in scientific or patent literature until Japanese laboratories initially detected it in July 2012 as an ingredient in synthetic cannabis smoking mixtures. Much like its closely related counterpart, …
Summary AM-2232, known chemically as 1-4-cyclobutyl)-3-(naphthalene-1-oyl)indole, is a potent yet non-specific agonist for cannabinoid receptors. It exhibits a Ki of 0.28 nM at CB1 and 1.48 nM at CB2, indicating its affinity for these receptor types.In the United States, all CB1 receptor agonists belonging to the 3-(1-naphthyl)indole class, including AM-2232, are classified as Schedule I …
Summary AM-1235, also known as 1-(5-fluorophenyl)-3-(naphthalene-1-oyl)-6-nitroindole, is a potent and moderately selective agonist targeting the cannabinoid receptor CB1. Identifiers IUPAC name CAS Number 335161-27-8 ChemSpider 26633899 UNII 2HV9AH611M CompTox Dashboard (EPA) DTXSID10187159 Chemical and physical data Formula C24H21FN2O3 Molar mass 404.441 g·mol−1 Pharmacology Pharmacodynamics AM-1235 functions as a cannabinoid receptor agonist, with a Ki value of …
Summary AM-1221 is a potent and selective agonist that primarily targets the cannabinoid receptor CB2, exhibiting a remarkable Ki of 0.28 nM at CB2 and 52.3 Nm at CB1. This translates to an approximately 180-fold preference for CB2 over CB1. The presence of both 2-methyl and 6-nitro groups on the indole ring contributes to enhanced …
Summary AM-1220 is recognized for its potent and moderately selective agonistic effects on the cannabinoid receptor CB1, demonstrating approximately 19-fold selectivity for CB1 compared to the related CB2 receptor. This compound initially emerged in the early 1990s as a creation by a team led by Thomas D’Ambra at Sterling Winthrop. In the subsequent years, AM-1220 …
Summary AM-1248 is a compound with disputed potency and selectivity, acting as a moderately potent agonist for both cannabinoid receptors CB1 and CB2. When the typical 3-(1-naphthyl) group found in many indole-derived cannabinoid ligands is replaced with an adamantyl group, it often imparts significant CB2 selectivity. However, by incorporating an N-methylpiperidin-2-ylmethyl substitution at the indole …
