MPT, or N-methyl-N-propyltryptamine, is a synthetic tryptamine related to DMT. It has an unsubstituted indole ring and a terminal nitrogen carrying one methyl and one straight-chain propyl group. Its chemical structure was confirmed by single-crystal X-ray diffraction in 2019, but receptor pharmacology and human clinical effects remain largely unstudied.
Chemistry and identification
MPT is N-methyl-N-propyl-2-(1H-indol-3-yl)ethanamine. It is an unsymmetrical N,N-dialkyltryptamine, distinct from DPT, which carries two propyl groups, and MiPT, which has a methyl and an isopropyl group.
The 2019 crystallographic study determined the structure of MPT and described the way its molecules form one-dimensional chains through hydrogen bonding between the indole and amine groups. The authors noted that MPT had first appeared in the literature in 2005 and had not undergone significant study by the time of the crystal-structure report (Chadeayne, Golen and Manke, 2019).
Pharmacology
No compound-specific receptor-binding or functional assay for MPT was identified in the scientific literature reviewed here. Its structural relationship to other N,N-dialkyltryptamines may guide future research, but it is not sufficient to assign a 5-HT2A potency or a defined mechanism of action.
Results for DPT or 4-HO-MPT should not be treated as direct evidence about MPT. 4-HO-MPT contains an additional hydroxy group, which changes the molecule’s structure and may alter its receptor interactions.
Reported effects and clinical evidence
There are few reliable human descriptions of MPT, and no controlled clinical study has established a characteristic subjective profile. The crystal-structure paper confirms the identity of the compound, not its psychoactive effects.
Research limitations
Human metabolism, acute toxic range, dependence potential and long-term effects remain unknown. Its chemical characterisation is not matched by a comparable understanding of its pharmacology.
Related tryptamines
MPT is related to MiPT, MET, DET and DPT. Its methyl-propyl nitrogen substitution distinguishes it from the symmetrical and branched-chain analogues.
