4-HO-DiPT, also known as iprocin, is a synthetic tryptamine with a hydroxy group at the 4-position of the indole ring and two isopropyl groups on the terminal nitrogen. It is related to psilocin and to the acetylated analogue 4-AcO-DiPT. Receptor studies show activity at several serotonin subtypes, while human descriptions remain largely anecdotal.
Chemistry and identification
4-HO-DiPT is 4-hydroxy-N,N-diisopropyltryptamine. Its two isopropyl groups distinguish it from 4-HO-DET, which has two ethyl groups, and from 4-HO-MiPT, which has one methyl and one isopropyl group.
Receptor pharmacology
A 2023 study examined 4-HO-DiPT at human 5-HT1A, 5-HT2A and 5-HT2C receptors. In the 5-HT2A functional assay, it acted as a high-efficacy agonist, with an EC50 of approximately 334 nM and a response slightly above the serotonin reference maximum. It showed a different profile at 5-HT1A, where it behaved as a partial agonist (Kozell and colleagues, 2023).
These findings demonstrate activity across multiple serotonin receptors. They do not establish human potency or predict the intensity of subjective effects.
Reported effects
Descriptions of 4-HO-DiPT are mainly anecdotal. A recent review summarises reports of a relatively rapid psychedelic experience and prominent changes in auditory perception. These accounts offer historical descriptions, not controlled clinical evidence (Tryptamine-based drugs, 2024).
Relationship to 4-AcO-DiPT
4-AcO-DiPT is the acetate ester of 4-HO-DiPT. Human hepatocyte experiments found that ester hydrolysis produced 4-HO-DiPT as the first-generation metabolite, followed by N-dealkylation, oxidation and conjugation pathways. This provides direct metabolic evidence for the relationship between the two compounds, although it does not establish the pharmacokinetics of 4-HO-DiPT itself (Malaca and colleagues, 2022).
Toxicology and research limitations
There are no large controlled human studies defining the acute toxic range, dependence potential or long-term effects of 4-HO-DiPT. The receptor assays and metabolic work provide useful biological context, but the clinical evidence remains limited.
Descriptions of 4-AcO-DiPT cannot automatically be applied to 4-HO-DiPT, despite their close structural relationship and metabolic connection through hydrolysis.
Related tryptamines
4-HO-DiPT is related to 4-AcO-DiPT, 4-HO-DET, 4-HO-DPT and 4-HO-MET. Its N,N-diisopropyl substitution distinguishes it from the other 4-hydroxy tryptamines.
