FAB-144

FAB-144 is a synthetic cannabinoid identified in chemical databases as 5F-UR-144 indazole. It is the indazole analogue of XLR-11, with a 5-fluoropentyl chain and a tetramethylcyclopropyl ketone group. The name can be confused with FUB-144, but the compounds have different structures: FAB-144 contains an indazole ring, while FUB-144 is an indole analogue with a fluorobenzyl substituent.

Chemistry and identification

UNODC lists FAB-144 as (1-(5-fluoropentyl)-1H-indazol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone, also called 5F-UR-144 indazole. The formula is C₂₀H₂₇FN₂O. This structure differs from XLR-11, which contains an indole rather than an indazole ring (UNODC substance record: FAB-144).

Reference-standard documentation describes FAB-144 as an analogue of XLR-11 and notes that its physiological and toxicological properties were not known in the available product information (Cayman Chemical analytical reference standard).

Pharmacology

There is little direct experimental evidence defining FAB-144’s activity at CB₁ and CB₂ receptors. Its structural relationship to XLR-11 and its listing as a synthetic cannabinoid receptor agonist suggest cannabinoid activity, but the sources reviewed here do not reliably establish its potency or efficacy.

It would be inaccurate to assume that FAB-144 has the same receptor selectivity as XLR-11. Replacing an indole ring with an indazole can change receptor interactions, metabolism and functional activity.

Reported effects

No reliable human effect profile has been established for FAB-144. There are no controlled human studies or well-characterised clinical case series in the sources reviewed here. Reported effects of XLR-11 or other synthetic cannabinoids are not direct observations of FAB-144.

Toxicity and research limitations

The available reference material explicitly notes that the physiological and toxicological properties of FAB-144 are unknown. Its metabolism, acute toxic range, dependence potential and long-term effects remain uncharacterised.

The key editorial distinction is between confirmed chemical identity and inferred pharmacology. FAB-144 has a documented structure and appears in synthetic cannabinoid databases, but those facts do not establish the strength or nature of its effects in humans.

Related compounds

FAB-144 is related to XLR-11 and FUB-144. It is the indazole analogue of XLR-11, while FUB-144 is a fluorobenzyl-substituted indole compound.